Eterna invites contributors to become RNA scientists. Contributors solve puzzles to design specialized RNA-based medicines and sensors, receive feedback after their designs are built and tested in university labs, and work together to build knowledge about how RNA works. In response to the SARS-CoV-2 pandemic, Eterna joined the OpenVaccine project to learn more about how mRNA degrades and develop a new method for designing mRNA vaccines. The resulting highly structured spike protein sequences have the potential to triple the refrigerated shelf life of existing mRNA vaccines. The ongoing OpenRibosome project offers citizen scientists the opportunity to help reengineer the E. coli ribosome for laboratory use (and eventually polymer and therapeutic applications) while learning about ribosome structure and function.