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Humans have modified most of the Earth’s land surface, and the resulting changes affect many organisms, including disease-transmitting mosquitoes. Land use and land cover influence mosquito habitat through multiple pathways, including the availability of temporary water bodies, suitable microclimates, and hosts to provide blood meals. These effects vary geographically depending on the mosquito species and the characteristics of the local environment. This talk will present several case studies using satellite remote sensing to study connections between land cover and mosquito-borne disease transmission. The opportunities and challenges of studying these relationships will be discussed.