Open Source Malaria (OSM) is aimed at finding new medicines for malaria using open source principles, embodied in the 6 Laws of Open Research. At the moment the majority of work involves the synthesis of analogs of compounds identified by big pharma, with the aim of improving their potency while making the molecules more "druggable", what is known as a "hit-to-lead" campaign.
Medicinal chemists should head to the project summary, then the individual compound series page. The most active series at the moment is Series 4.
For a good general overview, see the April 2014 newsletter, which can be downloaded as a PDF here. Answers to many common questions can be found in the FAQ page
This wiki describes where the project is up to, and archives some data and loose ends. For everything else about the project, see the main Project Landing Page. For a list of current to do items that can be filtered by type and series, see the To Do List.
About OSM, What's Needed and how to Contact
The background to the project may be found in the Story so Far. Publications from the project and other outputs are in the Links page, along with media about the project.
The main resources needed in the OSM project are experimental input, particularly chemical compound synthesis and help with chem/bioinformatics. Anyone can make compounds, get them tested and contribute data. You don't have to be a research scientist - maybe you're an undergrad doing a lab.
If you have no access to a lab, there are a number of important other things needed, labelled as such on the To Do List, such as things to do with writing or PR to help spread the word.
Ideally everything happens in the public domain through any of the ways shown on the Landing Page but you can in the last resort contact the consortium using firstname.lastname@example.org