How does life that’s evolved here on Earth react to the radiation-rich, gravity-poor environment of space? It’s an important question to ask before we send people to Mars or anywhere else in the solar system. The Open Science Data Repository Analysis Working Groups (OSDR AWGs) are teams of people - scientists, students, and members of the public - working together to answer this question. The nine Analysis Working Groups examine data from NASA missions and space experiments collected in the Open Science Data Repository (OSDR). These teams use the data to answer questions in basic science, applied science, and health outcomes for space exploration. Dozens of project groups are active at any time. The OSDR provides free and open data analysis/visualization tools for anyone to use, and free, open, on-demand trainings for youth, students, and the public to learn bioinformatics, artificial intelligence, and machine learning for space biology. Your ideas and collaborative research may enable the next breakthrough to help life thrive in deep space! The current Analysis Working Groups are listed below. Each perform the two functions of AWGs - providing feedback to data standards and conducting analysis of data within the OSDR - for their disciplinary area. - The Animal AWG focuses on data from experiments with animal in space, seeking to better understand basic animal science as well as animal evolution and adaptation to the conditions of space. The experiments work with rodents, fruit flies, roundworms, and tissue-on-a-chip technology. - The Artificial Intelligence/Machine Learning (AI/ML) AWG develops and deploys AI and ML tools to answer questions about spaceflight biology and human health. - The NASA Ames Life Sciences Data Archive (ALSDA) AWG focuses on physiological, phenotypic, biomedical, imaging, and behavioral data. This group spends a majority of its time on data and metadata standards. - The Female Reproductive System AWG investigates the impacts of spaceflight on female reproductive health, from endocrinology to reproductive organ health. - The Human AWG investigates the direct impacts of living in space on human health and works to connect an individual’s response to space to their genetics, physiology, biochemistry, etc. to better predict health outcomes. - The Microbial AWG investigates microbial life and the ecosystems to support life in space; investigations address bacteria, yeast, viruses, and other types of microbiological life. - The Multi-Omics AWG. Each ‘omics discipline examines a different biological molecule (e.g. DNA) and its functions throughout the body of an organism. The Multi-Omics AWG integrates data from all the ‘omics disciplines to investigate how the environment of space impacts terrestrial life. - The Plants AWG focus on the science of cultivating healthy, nutritious plant crops in space. - The RadLab AWG focuses on radiation telemetry (the science of remotely detecting and measuring radiation in space and converting those data to signals that can be transmitted) and radiation biophysics (the study of how radiation impacts the physics of cellular processes). This AWG was instrumental in guiding the creation of the ‘RadLab’ tools of the OSDR.